Posted: December 21st, 2015

Discuss the challenges of producing 250mg tablets of the two drugs using direct compression. Discuss what excipients (give at least three examples) and production measures could be used to overcome the challenges.

The following is the physical properties of two drugs. Discuss the challenges of producing 250mg tablets of the two drugs using direct compression. Discuss what excipients (give at least three examples) and production measures could be used to overcome the challenges.

Drug A: 10mg dose, poor flow properties and poor compaction properties

Drug B: 50mg dose, poorly water soluble, micronized particles, reasonably good compaction properties

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