Osteonin – a possible treatment for osteoporosis.

The drug Osteonin inhibits the activity of osteoclasts which normally break down bone.

work out what effect will this have on blood calcium levels over 24 hours, since the drug will greatly reduce the ability of osteoclasts to release calcium from the bones into the bloodstream, even when it’s needed.

what effect this will have on the function of nerve and on blood clotting.

Finally you need to argue how a person who is being treated with Osteonin might reduce these side effects.

If Osteonin reduces osteoclast activity by 90% the this should lead to less calcium output from bones, but the essay question also says osteonin has no effect on parathyroid hormone levels. But parathyroid hormone normally affects the activity of osteoclasts, so has the drug altered the structure of parathyroid hormone or somehow made it ineffective?

When blood calcium levels are high the osteoblasts will respond to the increased secretion of calcitonin (by the thyroid) and deposit the excess calcium in bones.

Knowing that, you can work out what will happen to the levels of blood calcium over 24 hours, because the only source of calcium they will be able to use to keep blood calcium at the right level will be in what they eat and drink.

If calcium is consumed, does vitamin D still help absorb it from the gut (even though the osteoclasts are not very functional)? The text book states ‘vitamin D3 is to serve as a cofactor with PTH to increase intestinal absorption of calcium’

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