Posted: August 16th, 2016

Discuss the factors that are likely to have contributed to Sam’s presentation. (Hint: consider the consequences of long-term lithium use and the mechanism of lithium clearance

Question:
Discuss the factors that are likely to have contributed to Sam’s presentation. (Hint: consider the consequences of long-term lithium use and the mechanism of lithium clearance) (300 words; 3 marks)
answer here
9- Inter-Individual Variability
As a new targeted anti-cancer drug ‘FCIC-15’ enters Phase III clinical trials, it is determined that the drug requires hepatic activation in order to elicit a therapeutic effect. Further studies identify that the sole enzyme involved in the activation of this drug is CYP2C19.

Question:
a) Select ONE specific factor (from the categories environmental, genetic or physiological) that may contribute to inter-individual variability in the activation of ‘FCIC-15’, and explain the potential consequences of this variability in terms of treatment response and tolerability. (200 words; 3 marks)
b) Briefly discuss how this variability may be controlled for in clinical practice. (100 words; 1 mark)
answer= answer here