Posted: December 21st, 2015

Discuss the advantages of formulating drugs in development as soft gelatin capsules compared with a tablet formulation in relation to their manufacture, bioavailability and applicability to BCS class II and class IV compounds

It is estimated that more than 40% for new chemical entities coming out of the current drug discovery process have poor biopharmaceutical properties such as low aqueous solubility and/or permeability. This poses a significant challenge for the oral absorption of new drug compounds and for the development of orally bioavailable dosage forms. Discuss the advantages of formulating drugs in development as soft gelatin capsules compared with a tablet formulation in relation to their manufacture, bioavailability and applicability to BCS class II and class IV compounds.